PHA 6791 Systematic Review & Meta-Analysis for Pharmaceutical Interventions


The purpose of this course is to enable students to be able to participate in and complete systematic reviews for pharmaceutical interventions and to complete meta-analyses. Students will learn how to build a team, formulate research questions and hypotheses, develop search strategies, and abstract, collect and report data. Students who complete this course will understand the importance of systematic reviews in making clinical and policy decisions in health care.

Upon successful completion of this course, the student will be able to:

  1. Differentiate systematic reviews from other types of assessments (e.g., narrative reviews, scoping reviews).
  2. State the role of systematic reviews and meta-analyses in pharmaceutical value assessment and communication.
  3. Define appropriate research questions for a systematic review and meta-analysis.
  4. Conduct an appropriate search strategy for a systematic review.
  5. Apply eligibility (i.e., inclusion and exclusion) criteria, data extraction, and data quality assessment.
  6. Explain how to do data synthesis for meta-analysis.
  7. Calculate effect sizes and confidence intervals.
  8. Identify and quantify heterogeneity.
  9. State when to use a fixed versus random-effects model.
  10. Develop a plan for data synthesis.
  11. Execute a meta-analysis of randomized controlled trials or observational studies.
  12. State the importance of and assess for publication bias and other potential sources of bias.
  13. State when a meta-analysis should not be done and how to report a systematic review instead of a meta-analysis.
  14. Explain the special considerations for applying meta-analyses to economic evidence, patient reported outcomes, a network of randomized controlled trials (network meta-analysis), or drug safety.

Tuition:  $2,250
Credits: 3

*Please note that this syllabus is subject to change. Use the updated syllabus in Canvas as the official course syllabus.